Changes in the intestinal microbiota of farmed northern sheatfish (<i>Silurus soldatovi</i>) associated with natural bacterial infection

An acute infectious disease of northern sheatfish (Silurus soldatovi) was found in a commercial aquaculture pond Tianjin, China. Herein, two dominant bacterial strains were isolated from naturally diseased and identified as Aeromonas veronii Vibrio cholerae. Seven healthy seven fish that collected the used for gut microbiota analysis by high-throughput 16S rRNA gene sequencing. The α-diversity indices (ACE, Chao 1, Shannon) did not differ significantly between (p > 0.05), but significant separation observed them when β-diversity population performed. demonstrated elevation relative abundances Aeromonas, Vibrio, Blautia, Megamonas decrease Cetobacterium, Bacteroides, Chryseolinea, Ralstonia, Pseudomonas compared with < 0.05). Linear discriminant effect size showed microbial marker species order Aeromonadales, family Aeromonadaceae, genus Aeromonas. functional profiles community predicted using PICRUSt2 indicated disturbance caused alteration its fish.